Gene name:
LYVE1 (CRSBP1;XLKD1) ;
Protein name:
Lymphatic vessel endothelial hyaluronic acid receptor 1 (LYVE-1) ;
Alternative:
Extracellular link domain-containing protein 1 ;Cell surface retention sequence-binding protein 1 (CRSBP-1) ;
Organism:
Bovine (Bos taurus).
General Annotation
Sub Unit:
Homodimer; disulfide-linked. Interacts with PDGFB and IGFBP3. Forms a transient ternary complex with PDGFB and PDGFRB in TGN.
Function:
Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as an hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.
Subcellular Location:
Membrane
Single-pass membrane protein
Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-dependent internalization and recycling at the cell surface.
Protein Attributes:
50:
MAKFFSLGLL | LASIWTTRLL | VQGSLRSEEI | SILGPCRIMG | VTLVTKKTQP |
100:
LLNFTEAQEA | CRLVGLTLAS | QDQVEEARKF | GFETCSYGWV | KNQFVVIPRI |
150:
ISNPKCGKSG | VGVVIWRSSL | SSRHRSYCHN | SSDIWINSCL | PEIITTDDPL |
200:
FNTETATYTT | KLMVSDSTHS | ELSTDGPDYV | TTTVAPPLAS | TSTPRKRKLI |
250:
CITEAFMDTS | AVATERESDI | QNRPAFKNEA | VGFGGVPTAL | LVLALLFFAA |
300:
AAGLAVCYVK | RYVKAFPFTN | KNQQKEMIET | KVVKEEKADD | SNPNEESKKM |
322:
NKTPEEPKSP | PKTTVRCLEA | EV
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Bovine
ELISA Kit for Bovine LYVE-1
ELISA Kit for Bovine LYVE-1
ELISA Kit for Bovine LYVE-1
CLIA Kit for Bovine LYVE-1
CLIA Kit for Bovine LYVE-1
CLIA Kit for Bovine LYVE-1
Polyclonal Antibody for Bovine LYVE-1
Polyclonal Antibody for Bovine LYVE-1
Polyclonal Antibody for Bovine LYVE-1
Monoclonal Antibody for Bovine LYVE-1
Monoclonal Antibody for Bovine LYVE-1
Monoclonal Antibody for Bovine LYVE-1
Protein for Bovine LYVE-1
Protein for Bovine LYVE-1
Protein for Bovine LYVE-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;INTERACTION WITH PDGFB AND IGFBP3;GLYCOSYLATION;SUBUNIT